Background: Plasma gel is a new procedure in the aesthetic field. It has been used for various dermatological conditions including wound healing, anti-inflammatory, and cosmetic uses. Infra-orbital dark circles possess no medical harm but signifies cosmetic and psychological burden. Objective: Evaluation the efficacy and safety of plasma gel (Filler) injection and comparing its result with polydiaxone (PDO) mono threads in peri-orbital rejuvenation by subjective measure using a 3D computerized camera which gives a report with very fine details. Patients and methods: 40 patients with infra-orbital fine wrinkles were included and by the Antera 3D camera, these fine wrinkles were divided to small sized and medium sized wrinkles and evaluated for the changes in the size and depth, indentation index and texture roughness of the wrinkles. Patients underwent plasma gel injections into the infra-orbital area of the left eye and PDO mono threads insertion in the right side. All patients were evaluated using the Antera camera at day (0m), after one month (1m) and after 6 months (6m) of the therapy. Results: Antera reports of the side injected with the plasma gel showed very good response. Also PDO mono threads insertion revealed marked cosmetic results, yet the efficacy of the plasma filler was superior as regards wrinkle's size, indentation index and texture roughness. .