Background: The effect of COVID–19 re-infection is not fully clear. Patients may have a benefit or no change in the degree of illness if re-infected with the COVID-19 virus. Objective: This study aimed to estimate the incidence of re-hospitalization due to COVID–19 re-infection and to characterize the features of those re-hospitalized patients. Patients and Methods: A retrospective cohort study from the COVID-19 patients' registration data in Kafr El-Sheikh governorate, Egypt in the period from September 2020 to July 2021. The study population was 1000 patients who had re-infection with the covid-19 disease, at least four months after hospital discharge. The patient presentations included fever, cough, dyspnea, diarrhea, or fatigue plus: polymerase chain reaction confirming infection with SARS-COV2 and/or computed tomography (CT) chest suggesting covid-19 infection.  Results: Among the study population, there were two (0.2 %), re-hospitalized, due to COVID-19 re-infection. Symptoms with re-hospitalization were fever 100%, cough 100%, tachypnea 100%, and fatigue 50%.  Conclusion: Once hospitalized; COVID-19 patients significantly have a very low risk of re-admission if re-infected. Clinical approach to COVID-19 patients should consider the history of previous hospitalization due to COVID-19. This history will help in the management including treatment, need for hospital admission, and initial prognosis. All study populations didn't receive the COVID-19 vaccine as the study period was before or just after authorization and availability of the vaccine.