Background: Physical activity (PA) is such movements that resulted from any muscular or skeletal movements that require energy expenditure. This includes all types of human movements such as competitive sports and exercise or the daily activities. PA is a key factor in reducing the risk of many chronic diseases and promotes psychological well-being; only if practiced throughout the life span. Objectives: The current study aimed to determine the prevalence of PA and its predictors among Sohag University students. Patients and Methods: A cross- sectional study was conducted among 536 students of Sohag University in four randomly chosen faculties during the academic year 2020/2021. A self- administered questionnaire was used for collecting data about socio-demographic characteristics; the second section was the International Physical Activity Questionnaire (IPAQ). Results: Most of the participants (95%) were physically active. Most females (99.2%) were physically active compared to males (91.3 %). Students enrolled Faculty of Literature and Faculty of Law were more active (98.4% and 955%, respectively) than others in Faculty of Engineering and Faculty of Medicine (90.4% and 81.5%, respectively). The studied students in the fourth grade were the most physically active (97.4%). Females spent more time in domestic activities than males. Regarding work while studying, the studied students who work were physically active (99.2%) much more than those who didn't work (93.8%). Predictors of PA among Sohag University students were being a female and student in Faculty of Literature and Faculty of Law.