Background: Diabetic Ketoacidosis is one of the leading causes of intensive care unit (ICU) admissions. Recently, evidence suggests that procalcitonin (PCT) and lactate levels are helpful prognostic markers for diabetic ketoacidosis. Objective: To assess the PCT and serum lactate levels as predictors for morbidity and mortality in DKA patients admitted to the ICU. Patients and Methods: A prospective study included 180 patients conducted at Mansoura University Hospitals, Mansoura, Egypt, for a duration of 1.5 year-duration from January 2021 to June 2022. All patients had been subjected to clinical examination and medical history. Laboratory tests, comprising a complete blood count, PCT, and serum lactate levels were reported. Results: The median PCT level in the DKA group was 7.18 ng/ml, the median PCT level in the diabetic group without DKA was 5.8 ng/ml and in the control group, the median level was 0.7 ng/ml. The mean serum lactate level in the DKA group was 7.66 ± 0.86 mmol/L, the mean serum lactate level in the diabetic group without DKA was 4.11±0.77 mmol/L and in the control group, the mean serum lactate level was 2.01 ± 0.39 mmol/L. Conclusion: PCT and lactate levels were significantly higher in the DKA group in comparison to the diabetic without DKA group and the control group.