Background: As a result of the COVID-19 pandemic, healthcare providers are rethinking how they deliver care, interact with patients, and handle cases of diabetes in children in unprecedented ways. Family behavior may have increased diabetic ketoacidosis (DKA) due to the COVID-19 pandemic. Objective: The purpose of the current study was to evaluate serum COVID-19 IgG and IgM antibodies level in pediatric type 1 diabetes mellitus (T1DM). Patients and methods: A cross-sectional study was conducted on 36 patients newly diagnosed T1DM children presented by DKA or known diabetic exposed to DKA. The study was carried out between June and December of 2021/22 at Zagazig University's Paediatric Intensive Care Unit (PICU). COVID-19 IgG and IgM Antibodies were assessed among all patients. Results: Antibodies differed significantly as regard DKA severity, Serum ferritin, D-dimer and CRP. Antibodies differed significantly as regard white blood cells and lymphocytes. The mean HbA1c was 8.99 (SD 0.97) with range from 7.2 to 11. There were 58.3% were newly diagnosed T1DM and 41.7% were known diabetic. Conclusion: Evidence linked SARS-CoV-2 infection with T1DM. SARS COVID-19 IgG and IgM were detected in 36% of our studied group while the rest were negative for IgG and IgM.