Objective : The study was designed to compare 4 different commercially available brands of clear aligners based on their plaque retention properties after 14 days of wear. Methods:  26 aligners were evaluated under each brand, making it a total of 104 aligners. ATP Bio-luminescence was used to quantify the microbial plaque adherent to the inner surface of aligners after being thoroughly rinsed, dried and cleaned. The patients were also asked to fill out an oral hygiene proforma, to eliminate the subjective factors. to remove any patient subjectivity (rewrite). Results: The plaque retention on different brands of clear aligners after 14 days of wear showed no statistically significant difference. However, a positive correlation was observed between oral hygiene habits such as frequency of brushing and mouthwash, habits's remove) frequency of consumption of sugar added drinks and plaque retention on the aligner surface. Conclusion: The 4 brands of commercially available clear aligners studied were highly comparable with no significant difference in terms of plaque retention.