Background: Cardiorenal syndrome, a term used to describe a variety of heart and kidney illnesses, is characterized by the dysfunction of one organ resulting to the dysfunction of the other. Objective: The aim of the current study to evaluate some biochemical indicators, linking hematologic analysis and kidney function test with interleukin-1 receptor family biomarker (ST2), and investigating the early diagnosis and prediction of chronic renal syndrome. Patients and methods: A total of 60 cases were recruited; comprising 20 controls and 40 patients with chronic kidney disease and cardiovascular disease. The patients were aged between 25 and 65 years old. Levels of ST2 were measured in both the case and the control groups. Result: In comparison with the control group, patients with cardiovascular diseases had higher concentrations of haematological features than do patients with chronic kidney disease. Also, when compared to controls, those with chronic kidney disease had statistically significant (P<0.05) increase in their serum levels of urea and creatinine. When compared to other groups, the levels of the biomarker ST2 were significantly higher in chronic kidney disease patients. Conclusions: Adults with chronic kidney disease had higher circulating ST2 levels and a higher mortality rate. RBC negatively affects ST2 levels as a result there is a link between ST2 levels and the risk of anaemia in chronic kidney disease patients.