Introduction: The cardio-vascular disease is a reason for mortality and morbidity is a serious and expanding issue. Cardiotoxicity is a frequent adverse pharmacological reaction, and the anthracycline class of anticancer medications, in particular, causes significant cardiotoxicity. Oxidative stress, free radical production, and hypoxia are common mechanisms causing cardiotoxicity. Objective: The aim of the current study is to determine which pharmaceuticals and adverse drug reaction cardiac problems are detected in Iraqi Public Sector. Material and methods: By examining the reported adverse medication responses in terms of their seriousness, severity, preventability, and expectedness. Individual case safety records from the Ministry of Health and Pharmacovigilance of Iraq were examined retrospectively in this study. Results: The study comprised 2453 reports of adverse medication reactions with 1101 individual case safety reports. The medicine with the most adverse drug reactions was tozinameran. Cardiac diseases were the cause of the majority (46.73%) of negative medication responses. In terms of the degree of adverse medication responses, the majority were found to be light [Level 1 (38.4%). Patients under the age of 18 experienced much more severe adverse medication responses than did adults and the elderly. According to a severity evaluation, the majority of adverse medication responses (47.6%) were not severe. The majority of negative drug reactions (97.9%) were likely avoidable. Conclusion: Most reported cardiac adverse drug reactions were low in intensity, predictable, not life-threatening, and most likely preventable. The lack of information in the Individual Case Safety Report (ICSR) impacted how the reports were evaluated, necessitating the creation of training initiatives to create a stronger reporting system.