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283666

Urinary Tract Infection after Surgical Correction of Female Patients with Congenital Adrenal Hyperplasia

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Last updated: 03 Jan 2025

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Abstract

Background: Congenital adrenal hyperplasia (CAH) is the most common cause of virilized females with disorders of sexual differentiation (DSD) with46XX karyotype. Objective: To prospectively investigate the correlation between surgical correction using single surgical technique (partial urogenital sinus mobilization) and the occurrence of urinary tract infection in female patients with congenital adrenal hyperplasia (CAH). Methods: Our study included 27 CAH female patients who follow up in urology and endocrinology clinic in Cairo university hospitals. We prospectively followed the patients over a period of 4 years. Prader grade of virilization of the patients ranged from II to V. Before surgical correction patients were assessed by filling questionnaire by their parents, doing urine analysis and urine culture. Postoperative assessment by same tools was done after one month, then every three months. Follow up period extended from 26 to 42 months. Results: Two patients were classified as Prader type two (7.4%), ten patients as Prader type III (37.1 %), thirteen patients as Prader type IV (48.1%) and two patients as Prader type V (7.4%). All patients were well controlled before surgery with preoperative 17- OH progesterone ranging from 0.16 to 6 ng/dl (Mean ±SD: 1.532 ±1.77). All patients had negative preoperative urine cultures for infection .Postoperative urine analysis and cultures were positive for infection in seven patients (25.9%) after one month of surgery. Conclusions: Long term urinary tract infection rates don't increase after surgical reconstruction of female patients with partial urogenital sinus mobilization even If early postoperative urinary tract infection rates were high.                                            

DOI

10.21608/ejhm.2023.283666

Keywords

partial urogenital sinus mobilization, CAH, urinary complications, UTI

Authors

First Name

Mohamed Ahmed

Last Name

Ateya

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First Name

Noha

Last Name

Arafa

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First Name

Mona Hassan

Last Name

Hafez

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First Name

Hani

Last Name

Morsi

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First Name

Ahmed M

Last Name

Shouman

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Volume

90

Article Issue

1

Related Issue

38787

Issue Date

2023-01-01

Receive Date

2023-02-01

Publish Date

2023-01-01

Page Start

1,588

Page End

1,591

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_283666.html

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https://ejhm.journals.ekb.eg/service?article_code=283666

Order

236

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Urinary Tract Infection after Surgical Correction of Female Patients with Congenital Adrenal Hyperplasia

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Article

Created At

24 Dec 2024