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The Rho Kinase Inhibitor Fasudil Mitigates Neurocognitive Deficits in D-Galactose-Induced Brain Aging in Rats: Involvement of SIRT1, BDNF and NF-κB

Article

Last updated: 24 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Neurophysiology

Abstract

Abstract
Introduction: Cognitive deficits and aging were evoked by D-galactose (D-gal). Fasudil (Fsd) slows the start and progress of neurodegenerative illnesses.
Objective: to illustrate the neuroprotective effect of Fsd in D-gal induced cognitive deficits and the underling mechanisms involved
Material & methods: Thirty Wister albino male rats divided into control, D-gal, D-gal+Fsd groups. Rats were subjected to MWM, NOR and EPM tests then rats were sacrificed and MDA, catalase, TNF-α, IL-6 hippocampal gene expression of BDNF, SIRT1 and NF-kB were assessed. Histopathological and immunoreaction for caspase-3 and GFAP were done.
Results: D-gal revealed cognitive impairment, with substantial elevation of MDA, TNF-α, IL-6 and NF-kB gene expression and significant reduction of catalase, SIRT1 and BDNF gene expression of D-gal with upregulation of caspase-3 and GFAP immunoreaction in hippocampus. Fsd dramatically improved D-gal induced changes.
Conclusion: Fsd alleviated D-gal induced cognitive deficits by anti-oxidant, anti-inflammatory, anti-apoptotic mechanisms in addition to up-regulation of Sirt1 and BDNF gene expression and improving gliosis.

DOI

10.21608/besps.2024.324333.1179

Keywords

SIRT1, BDNF, GFAP, D-galactose, Fasudil and NF-κB

Authors

First Name

Suzan

Last Name

Khodir

MiddleName

A

Affiliation

Medical Physiology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt.

Email

suzan.abdalhameed.12@med.menofia.edu.eg

City

-

Orcid

0000-0002-2535-9445

First Name

Hala

Last Name

El-Haroun

MiddleName

-

Affiliation

Histology and Cell Biology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia

Email

suzy25186@gmail.com

City

-

Orcid

-

First Name

Asmaa

Last Name

Shukry

MiddleName

Mahmoud

Affiliation

Medical Biochemistry and Molecular Biology Department, Faculty of medicine, Menoufia University

Email

asmaashukry1990@yahoo.com

City

-

Orcid

-

First Name

Tarek

Last Name

H. Abd-Elhamid

MiddleName

-

Affiliation

Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.

Email

suzy25186@yahoo.com

City

-

Orcid

-

First Name

Asmaa

Last Name

Seddek

MiddleName

Abdellatef

Affiliation

Medical Physiology Department, Faculty of Medicine, Suez Canal University

Email

asmaaseddek3@gmail.com

City

-

Orcid

-

First Name

Eman

Last Name

Samy

MiddleName

-

Affiliation

Neuropsychiatry Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia

Email

esamy1900@gmail.com

City

-

Orcid

-

First Name

Amany

Last Name

R. Mahmoud

MiddleName

-

Affiliation

Human Anatomy and Embryology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.

Email

soso_egy89@yahoo.com

City

-

Orcid

-

First Name

Amaal

Last Name

Nabil

MiddleName

-

Affiliation

Medical Pharmacology Department, Faculty of medicine, Suez Canal University Ismailia, Egypt

Email

amaalnabil83@gmail.com

City

-

Orcid

-

First Name

Karima

Last Name

Ahmed

MiddleName

El-Sayed

Affiliation

Medical Physiology Department, Faculty of Medicine, Suez Canal University

Email

karima_ahmed@med.suez.edu.eg

City

Ismailia

Orcid

0000-0002-6350-5511

Related Issue

-2

Receive Date

2024-09-27

Publish Date

2024-11-14

Page Start

18

Page End

31

Print ISSN

1110-0842

Online ISSN

2356-9514

Article File

BESPS3919311731535200.pdf

PDF . 1.1MB

Link

https://besps.journals.ekb.eg/article_391931.html

Detail API

https://besps.journals.ekb.eg/service?article_code=391931

Order

391,931

Type

Original Article

Type Code

567

Publication Type

Journal

Publication Title

Bulletin of Egyptian Society for Physiological Sciences

Publication Link

https://besps.journals.ekb.eg/

MainTitle

The Rho Kinase Inhibitor Fasudil Mitigates Neurocognitive Deficits in D-Galactose-Induced Brain Aging in Rats: Involvement of SIRT1, BDNF and NF-κB

Details

Type

Article

Created At

24 Dec 2024