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383948

Nrf2/HO-1 Pathway Mediates the Protective Impact of Metrnl on Oxaliplatin-Induced Peripheral Neuropathy in Rats

Article

Last updated: 24 Dec 2024

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Subjects

-

Tags

Neurophysiology

Abstract

Abstract

Introduction: While oxaliplatin (OXL) is an effective cancer chemotherapy, OXL-based therapy's practical usefulness is limited by its adverse effects, which include peripheral neuropathy (PN).Objective: to assess the potential underlying processes and the protective impact of metrnl in PN caused by OXL. Materials and Methods: There were three groups of thirty adult male albino rats: control, OXL and OXL+Metrnl groups (10/group). Electromyography (EMG) and nerve conduction velocity (NCV) were applied to rats, together with behavioral testing for pain and sensory abnormalities. The expression of several genes was evaluated in the sciatic nerve, including tissue MDA, (SOD), TNF-α, interleukin (IL)-6, IL-10, caspase-3, BDNF, nuclear factor E2‐related factor 2 (Nrf2), and homo-oxygenase 1 (HO-1). Additionally, histopathological evaluations of the gastrocnemius and sciatic nerve were carried out.

Results The OXL group exhibited mechanical and cold allodynia, as well as significantly higher levels of MDA, TNF-α, IL-6, and caspase-3 than the control group. It also significantly reduced NCV, EMG recordings, IL-10, as well as down-regulating BDNF, Nrf2 and HO-1 gene expression in the sciatic nerve. OXL-induced PN changes were significantly ameliorated in the OXL+Metrnl groups. Conclusion: Metrnl has valuable protective effects on OXL-induced PN via anti-oxidant, anti-inflammatory, inhibition of apoptosis and neurotrophic effects in addition to up-regulation of Nrf2 and HO-1 gene expressions.

DOI

10.21608/besps.2024.319683.1177

Keywords

BDNF, HO1, Metrnl, Nrf2, Oxaliplatin

Authors

First Name

Suzan

Last Name

Khodir

MiddleName

A

Affiliation

Medical Physiology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt.

Email

suzan.abdalhameed.12@med.menofia.edu.eg

City

-

Orcid

0000-0002-2535-9445

First Name

Hala

Last Name

El-Haroun

MiddleName

-

Affiliation

Histology and Cell Biology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia

Email

hala.elharoun@rst.edu.eg

City

-

Orcid

0000-0002-9938-3907

First Name

Ahmed

Last Name

Gaafar

MiddleName

Mohamed

Affiliation

Medical Physiology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt.

Email

amrahmad2004@gmail.com

City

Shebin El-Kom

Orcid

-

First Name

Mohamed

Last Name

A. Zayed

MiddleName

-

Affiliation

Medical Physiology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt.

Email

mohamed.zayed@med.menofia.edu.eg

City

-

Orcid

-

First Name

Sara

Last Name

Rizk

MiddleName

Kamal

Affiliation

Medical Biochemistry and Molecular Biology Department, Faculty of medicine, Menoufia University, Egypt.

Email

sara.kamal930@med.menofia.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

lashin

MiddleName

Elsaeed

Affiliation

Neuropsychiatry Department, Faculty of Medicine, Menoufia University.

Email

mohamed.alsaeed740@med.menofia.edu.eg

City

-

Orcid

-

First Name

Amira

Last Name

S. Mohamed

MiddleName

-

Affiliation

Pharmacology Department, Faculty of medicine, Suez Canal University.

Email

amirasaad@med.suez.edu.eg

City

-

Orcid

0000-0003-3650-262X

First Name

Karima

Last Name

Ahmed

MiddleName

El-Sayed

Affiliation

Physiology department, faculty of medicine, Suez canal university

Email

karima_ahmed@med.suez.edu.eg

City

Ismailia

Orcid

0000-0002-6350-5511

Related Issue

-2

Receive Date

2024-09-09

Publish Date

2024-10-04

Page Start

1

Page End

17

Print ISSN

1110-0842

Online ISSN

2356-9514

Article File

BESPS3839481727989200.pdf

PDF . 365.0kB

Link

https://besps.journals.ekb.eg/article_383948.html

Detail API

https://besps.journals.ekb.eg/service?article_code=383948

Order

383,948

Type

Original Article

Type Code

567

Publication Type

Journal

Publication Title

Bulletin of Egyptian Society for Physiological Sciences

Publication Link

https://besps.journals.ekb.eg/

MainTitle

Nrf2/HO-1 Pathway Mediates the Protective Impact of Metrnl on Oxaliplatin-Induced Peripheral Neuropathy in Rats

Details

Type

Article

Created At

24 Dec 2024