Alzheimer disease (AD), the most prevalent neurological disorder, is typified by cerebral neuron decline. In its earliest phases, AD triggers short-term memory fails, while in its later phases, it leads to long-term memory problems, fluctuations in mood, and withdrawal from society in elderly people. One highly neurotoxic material that aids in the deterioration of nerve cells is aluminum. Neurofilamentous defects and metabolic changes can also be brought on by long-term exposure to aluminum in the cerebral cortex. The current study evaluated Y maze learning assessments, acetylcholinesterase (AchE), oxidative enzymes, in homogenates of the cerebral cortex as well as histopathological assessment of cortex in normal, induced group by AlCl3 and treated by Asparagus sprengeri (A. sprengeri) and Lactobacillus plantarum (L. plantarum) extracts separately or in mixture. The use of either A. sprengeri or L. plantarum extracts was shown to substantially enhance the mental abilities of the induced animals. It also increased levels of oxidative enzymes, such as SOD and GSH, and decreased MDA enzymes, as well as essential neurotransmitter AChE enzyme in homogenates of the cerebral cortex. These findings were further supported by improvements in histological examination. Additionally, the effects of mixed therapies are more comparable to those of solo treatment. This study offered an evidence in using A. sprengeri or L. plantarum separately or together as herbal remedies to treat rats with aluminum chloride-induced Alzheimer's disease and improve cognitive function.