A combined bivalent inactivated Vaccine against rabbit haemorrhagic disease and Rabbit entero-toxaemia was prepared using aluminum hydrox-ide gel as an adjuvant . Efficacy of this vaccine comparing with monovalent ones against both disease was tested in 3 different groups of ma-ture rabbit and a control group . Evaluation of hu-moral immune response using the hemagglutina-tion inhibition test for RHDV and serum neutralization test for C. peifringens type A tox-oid was carried out , moreover a challenge test for RHDV was done . The prepared vaccine induced excellent and highly protective titer against both diseases. No mutal interference or competition occured and the vaccine could be used safely to protect rabbits against both diseases .