Dairy goats treated with oxytetracycline revealed a significant reduction in lymphocyte transformation which occurred 3 days post treatment and lasted for 4 weeks. At the same time thechemotactic index of PMN cells showed a significant· decline for 2 weeks. Decline in phagocytosis and killing percentage started on 3rd day and persist­ ed through the 2nd and 3rd weeks. No changes have been recorded for IgM, but IgG started to decline after one week and continued for 2 Weeks. Milk parameters recorded decrease in milk protein for two weeks and elevation in milk urea for one week and decline in milk lactose for 3 days. On the other hand no significant alteration on milk, fat, T.S., SNF. or SCC. has been recorded.