This study was carried out on 120 goats, 45 of them suffering from pneumonia with its clinical symptoms, 55 of them were died and 20 were ap­parently healthy. The morbidity and mortality rates reached 22.5% and 27.5%, respectively. A total of 25 nasal swabs were collected from pneumonic goat for isolation and identification of the causative agent. P. haemolytica was isolated pure in 44%. Other bacteria isolated coupled with Staphylococcus aureus in 24% and 32% Esheri­chia coil. The protein profiles of the purified bac­teria was carried out using SDS poly acrylamide gel electrophoresis by comparing with molecular weight marker changed from 10 - 250 KDa. This study was conducted to characterize and identify the purity of major porin proteins in outer mem­brane with molecular weight of 38 - 42 kDa . Of pasteurella heamolytica usin_b SDS-PAGE. In the active immunization assay, porin proteins 501.1g conferred 100% protection to challenged mice. In addition crud extract give 70% protection when challenged mice. Immunization with porin pro­teins of P.heaniolytica developed a significant in­crease in scrum antibody titre, as shown by en­zyme linked immunasorbent assay., Stability assay , and opsonophagocytic - killing assay.