A survey has done on 78 dogs of different ages and both sexes in Giza Governate to detect the incidence of the infestation with Spirocerca lupi in dogs. Fifty-eight cases were positively infected; only twenty-seven cases had clinical disease with the master sign if vomiting. The characteristic Spirocerca lesions were encountered mostly in aorta, esphagus and in few cases stomach involvement was also noticed. The most pronounced P.M lesions were the tumor like nodules in the last mentioned organs, those nodules contained cross-section of large number of the bright red worm in a yellow pus. Deformative degenerative spondylitis with associated aortic adhesive lesions was observed in 5 cases. Neoplastic reactions mainly fibrosarcoma was noticed in 11 cases which had the tendency to metastasis to the lung in  two cases.