The present study was conducted to evaluates the effect of Intraperitoneal use of sodium carboxymethylcellulose solution (1% & 2%) in prevention of experimentally induced abdominal adhesion, 15 healthy adult donkeys were allocated in 3 equal groups each of 5 animals. Group I kept as control while group II & III used as treated groups. In control group, donkeys were treated with a sterile solution of sodium chloride 0.9 % intraperitoneally. In treatment groups, donkeys were treated with a sterile solution of sodium carboxymethylcellulose (SCMC) in a dose of 7 ml/kg of body weight intraperitoneally in concentration of 19% for group I1& 2% for group IL After the end of the experimental period. histopathological examination was done to all groups. Results, revealed intraabdominal adhesions. associated with abraded, anastomotic sites and a distant segment of jejunum in all cases of control group. In treated donkeys with 1% SCMC solution, there were no adhesions detected in 4 donkeys but one case had adhesion between the jejunal abrasion site and the adjacent peritoneum. No adhesion was noticed at the anastomotic site. In treated donkeys with 2% SCMC solution, all cases had ecchymotic serosal hemorrhage at abrasion sites and mesentery with developed peritonitis.