This study was carried out on twenty-two donkeys subjected to jejunal and cecal serosal stripping adhesion induction model followed by intra- and post- operative peritoneal lavage for the fist three postinduction days. The chosen antiadhesive pharmaceuticals are dimethyl sulfoxide 20% solution; sodium chloride sterile solution containing 5000 IU heparin/liter; Ringer's lactate sterile solution containing 0.1% lavasept and 1% sodium carboxymethylcellulose. From the quantitative macroscopic and histopathological adhesions score system and the clinicopathological findings insignificant differences was found in the postsurgical adhesions scores among peritoneal lavage and control groups. The effectiveness of intraperitoneal lavage using dimethyl sulfoxide, heparin, lavasept and sodium carboxymethylcellulose in the prevention of adhesions cannot be scientifically supported because the results were controversial and lacked any implication for clinical use. No method has gained wide acceptance and surgeons must rely on meticulous surgical technique which can minimize tissue trauma and reducing the risk of postsurgical adhesions formation.