The study was carried out on 20 horses and 6 donkeys that were presented with exuberant granulation tissue on the distal limbs and divided randomly into two groups according to the used dressing materials. Surgical excision was done and the dressing materials were carried on the wound dressing sheets (kaltostat or aquacel). The selection of the dressing material depends on the stage of healing and the nature of the granulating ‘wounds. The tested dressing materials for group one are calcium-sodium alginate fiber (Kaltostat®), topical antibiotic spray (Tetravet® aerosal) and silver sulfadiazine cream (Dermazin®) and for group two are hydrofiber wound dressing (Aquace]®), fucidin® cream and pale sulfonated shale oils gel (Ichthol®). Fucicort® cream and zinc cxide cream (Zincosil®) were used in both group Histopathological examination was performed to samples from the exuberant granulation tissue. The results revealed that the use of kaltostat and aquacel as primary wound dressing in combination with the selected topical dressings in both groups may lead to acceleration of the rate of healing of the equine distal limb wounds without the development of exuberant granulation tissue.