Twenty formal parturient buffaloes, aged 4-8 years were eased in this study to clarify any association between lipid profiles, progesterone and postpartum fertility W Buffaloes. Based on the resumption of postpartum ovarian cyclicity, these animals were classified into three groups; buffaloes showing normal resumption of ovarian cyclicity at 65.18+19.90 days postpartum, buffaloes with delayed resumption of ovarian cyclicity at 138.33 = 16.50 days postpartum and buffaloes in anestrus up to 210 days postpartum. The involution of the uterus averaged 35.4 + 7.6 days without any significant difference between the three groups. Highly significant (P<0.01) differences were recorded in the calving to conception interval length between buffaloes with normal resumption of ovarian cyclicity and the others. A highly significant (P<0.01) negative correlation was recorded between the resumption of postpartum ovarian activity and serum levels of progesterone and total cholesterol. Also, a negative correlation (P<0.01) was recorded between the calving to conception interval and these biochemical parameters. No association was found between resumption of ovarian cyclicity or calving to conception interval with serum triglycerides concentrations.