This study was undertaken to evaluate the effectiveness of garlic and panax ginseng as dietary additions in alleviating the toxicity of aflatoxin By (AFB, ) in male Chinchilla rabbits. thirty rabbits ( 12-14. weeks age and mean body weight 1589 + 5.079 gm). were classified into nearly 6 similar groups in their average body weights : first and second groups served as positive and negative controls, third and fourth groups received Aflatoxin B, ( AFB, ) plus rather garlic or panax ginseng respectively. Fifth and sixth groups received only garlic and panax ginseng respectively. Rabbits were orally administered their respective doses of ( AFB, ) every other day for 10 weeks. The hematobiochemical parameters and enzymatic activites were evaluated. Results showed that AFB, significantly (P<0.05) decreased hemoglobin (Hb) total erythrocytic count (TEC) and (PCV). Garlic and panax ginseng caused an increase in these parameters and counteracted the negative effect of AFB, in the treated groups. Additionally, serum concentrations of total protein, albumin and glucose were significantly (P<0.05) declined by treatment with aflatoxin B). Garlic and panax ginseng caused non significant increases in these parameters and lessen the harmful effect of AFB,. On the other hand, aflatoxin treatment caused significant increases (P<0.05) in the activities of serum asparatate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in the treated groups also caused significant increases (p<0.05) in cholesterol and total bilirulin. Garlic and panax ginseng caused significant decreases in these parameters and alleviated the harmful effects of AFB).