The present study aimed to investigate the alteration of some chain breaking antioxidant levels as an indicator for the oxidative status of respiratory distress-affected calves. A total number of 20 calves were subjected to the study, of which, 10 animals were selected with various clinical manifestation of bronchopneumonia, while the other 10 calves were apparently healthy and used as a control group. Serum concentrations of B- carotene, vitamin A and ascorbic acid were measured in all animals. The results of the study revealed the presence of significant reduction (p<0.01) in serum B- carotene, vitamin A and ascorbic acid levels in bronchopneumonia affected calves as compared with control group. These findings suggest the elevation of the oxidative stress, manifested by the reduction of the chain breaking antioxidants, with the subsequent pathological affection in calves suffering from bronchopneumonia. The study points to the importance of vitamins supplementation during the treatment of respiratory distress-affected calves .