Rinderpest is a contagious disease that spreads at a very high rate and causes heavy mortality in buffaloes and other farm animals. The disease is manifested by high fever and watery diarrhea, pustular eruptions and ulcers which develop on the lips, gums, tongue and buccal mucosa. At present, Europe and most of Asia are free of the disease, except a few countries in south Asia beside Africa. In general buffaloes are susceptible to rinderpest. The disease has been reported from Egypt, India, Indonesia, Philippines, Malaya, Burma and Thailand (Mohan, 1968). Edward (1927) found that Indian buffaloes were more susceptible than cattle. Rapid diagnostic methods are available for the diagnosis of rinderpest by demonstration of either the antigen or the antibody, these include agar gel immunodiffusion (AGID) Scott and Broun, (1961), A localized Outbreak of Rinderpest in Egyptian counter immunoelectrophoresis (GIEP) (Ali and less 1979, Uppal et al., 1983). Complement fixation test (C.F.T), Scott et al. (1986) Passive haemogglutination (PHA) Singh et al. (1972), immunoperoxidase staining (Selvakumar et al., 1981), immunofluorescence (IF) Rossiter and Jessett (1982), virus neutratization (Plovuright and Ferris 1961), and enzyme linked immunosorbent assay (ELISA) test Rossiter et al., (1981). For controlling rinderpest, tissue culture vaccine (either using calf kidney or lamb kidney) is being extensively used. Tissue culture vaccine stimulates interferon production before neutralizing antibodies develop in buffaloes (Mohan 1968). A localized outbreak appeared suddenly among a group of buffaloes in the farm of Faculty of Vet. Med. Giza Egypt. The outbreak ran an acute course with clinical signs, post mortem lesions and high mortalities similar to those recorded in rinderpest of cattle. In the present investigation the clinical findings, P.M. lesions, the epizootiology observations Laboratory Investigation and the method of control are discussed.