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376632

TERATOGENICITY AND EFFECTS ON MALE FERTILITY OF THIODICARB INSECTICIDE IN ALBINO RATS

Article

Last updated: 03 Jan 2025

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Subjects

-

Tags

Pharmacology

Abstract

Thiodicarb (larvin)® was administered orally to pregnant female albino rats in doses of 3.98 and 1.99 mg/kg b. wt. daily at the organogenesis period (6-15th day of gestation). The administered doses resulted in decrease in number of implantation sites and survived feti and increased number of resorbed feti. The obtained results showed many visceral malformations (retarded growth, dilated cerebral ventricles, absence of thymus, atrophy of lungs and heart and dilated renal pelvis). Skeletal examination showed incomplete ossification of the skull, reduction in number of caudal and sacral vertebrae, absence of some sternbrae, incomplete pelvic girdle, fused tibia and fibula and absence of phalanges. In male albino rats, oral administration of 3.98 and 1.99mp/kg b. wt. for 65 days, resulted in decrease in sperm cell count, sperm motility and of live/dead sperms ratio.

DOI

10.21608/vmjg.1996.376632

Authors

First Name

AZIZA

Last Name

AMER

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Vet. Med. Cairo University

Email

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City

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Orcid

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Volume

44

Article Issue

4

Related Issue

50022

Issue Date

1996-10-01

Receive Date

2024-08-28

Publish Date

1996-10-01

Page Start

663

Page End

670

Print ISSN

1110-1423

Online ISSN

2537-1045

Link

https://vmjg.journals.ekb.eg/article_376632.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=376632

Order

376,632

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

TERATOGENICITY AND EFFECTS ON MALE FERTILITY OF THIODICARB INSECTICIDE IN ALBINO RATS

Details

Type

Article

Created At

23 Dec 2024