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376629

TESTING A NEW FORMULATION OF IVERMECTIN (IVOMEC POUR-ON & BOLUS) AS BROAD SPECTRUM PARASITICIDE

Article

Last updated: 03 Jan 2025

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Subjects

-

Tags

Parasitology and parasitic diseases

Abstract

  Two new formulations of ivermectin (MSD AGVET), Ivomec pour-on used for cattle in a dose of 1ml/10kg.b.w. and Ivomec bolus used per mouth for sheep in a dose of 1/2 bolus for each 25kg.b.w. (10 mg/50 kg.b.w.), were tested for control of natural infestation by gastrointestinal nematode parasites (G.I.N.) in cattle and sheep as well as for treatment of mange infection in sheep  The two drugs showed promising results in the form of freeing the treated animals from the target parasites by a percentage varies from 60-100% (in a mean of 85%) and decrease in the mean eps/gram feces (EPGF) from 695 on day zero to 15 EPGF on 35th day post-treatment (d.p.t.) for the pour-on form and 80-100% in sheep G.I.N. with marked decrease in the mean total EPGF from 756 on day zero to 8.3 EPGF in 28th d.p.t.  The bolus form succeeded in eradication of mange from the treated sheep by an efficacy varying from 82.69-100%. The two drugs showed absolute protection for the treated animals till 21st d.p.t. and very marked decrease in EPGF even for the still positive animals till end of the observation period. Cooperia, Nematodierus and Trichuris species appear slightly less susceptible to the used dose of the drugs than the other gastrointestinal nematode larvae. Concerning the pour-on form, the drug was easily administered, safe for the administrator, rapidly absorbed and did not show any post administration reaction while the bolus form needs some precautions during administration.  It is worthy to mention that changing the mode of  IVOMEC administration from injection to topical or swallowing way did not reflect the previous successful market known results of Ivomec injection, but it improved the drug application and use without decreasing its parasiticidal efficacy.

DOI

10.21608/vmjg.1996.376629

Authors

First Name

M.

Last Name

ABDEL-RAHMAN

MiddleName

-

Affiliation

Department of Parasitology, Faculty of veterinary Medicine, Cairo University ‘

Email

-

City

-

Orcid

-

First Name

M.

Last Name

EL-BAHY

MiddleName

-

Affiliation

Department of Parasitology, Faculty of veterinary Medicine, Cairo University ‘

Email

-

City

-

Orcid

-

First Name

N.

Last Name

EL-BAITY

MiddleName

-

Affiliation

Department of Parasitology, Faculty of Veterinary Medicine, Tanta University

Email

-

City

-

Orcid

-

First Name

E.

Last Name

RAMADAN

MiddleName

-

Affiliation

Department of Parasitology, Faculty of Veterinary Medicine, Tanta University .

Email

-

City

-

Orcid

-

Volume

44

Article Issue

4

Related Issue

50022

Issue Date

1996-10-01

Receive Date

2024-08-28

Publish Date

1996-10-01

Page Start

637

Page End

656

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 44_Issue 4_Pages 637-656.pdf

PDF . 15.3MB

Link

https://vmjg.journals.ekb.eg/article_376629.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=376629

Order

376,629

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

TESTING A NEW FORMULATION OF IVERMECTIN (IVOMEC POUR-ON & BOLUS) AS BROAD SPECTRUM PARASITICIDE

Details

Type

Article

Created At

23 Dec 2024