Beta
ManageSearchChatDiscover
376604

KINETIC DISPOSITION, SYSTEMIC BIOAVAILABILITY AND TISSUE DISTRIBUTION OF APRAMYCIN IN BROILER CHICKENS

Article

Last updated: 23 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Pharmacology

Abstract

  Apramycin was administered to chickens orally, intramuscularly and intravenous to determine blood concentration, kinetic behaviour, bioaviability and tissue residues. The drug was given through intracrop, i.m. and i.v. routes in a single dose of 75 mg kg-1 body weight. The highest serum concentrations of apramycin were reached 0.20 and 0.76 hours after a single oral i1.m. dosage with an absorption half-life [t 1\2 (ab)] 0.10 and 0.19 hours and elimination half-life [t 1\2 β)}1.21 and 0.53 hours, respectively. The systemic bioavailability percentage 2.03 and 57.96 percent after intracrop and i.m. administration, respectively, indicating the very lower extent of apramycin absorption from the oral route in chickens. Following i.v. injection, the kinetic of apramycin can be described by a two-compartment open model with a ( t 1\2 (α) 1.5 hours, (volume of distribution) Vd(ss) was 4.82 litre kg"! and CI(B) (total body clearance) was 1.88 litre k -1 h -1. The serum protein-binding ‘tendency of apramycin as calculated in vitro was 26 percent. The highest concentration of apramycin residues were present in the kidneys and liver after a successive daily intracrop and i.m. administration for 5 days. No apramycin residues were detected in tissues after 6 hours except in the liver and kidneys and that disappeared completely by 12 and 24 hours after intracrop and i.m administration, respectively

 

DOI

10.21608/vmjg.1996.376604

Authors

First Name

AFIFI

Last Name

A.

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, P.O. Box12211, Egypt.

Email

-

City

-

Orcid

-

First Name

RAMADAN

Last Name

A.

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, P.O. Box12211, Egypt.

Email

-

City

-

Orcid

-

Volume

44

Article Issue

2

Related Issue

50020

Issue Date

1996-04-01

Receive Date

2024-08-27

Publish Date

1996-04-01

Page Start

479

Page End

486

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 44_Issue 2_Pages 479-486.pdf

PDF . 6.5MB

Link

https://vmjg.journals.ekb.eg/article_376604.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=376604

Order

376,604

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

KINETIC DISPOSITION, SYSTEMIC BIOAVAILABILITY AND TISSUE DISTRIBUTION OF APRAMYCIN IN BROILER CHICKENS

Details

Type

Article

Created At

23 Dec 2024