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376575

DISPOSITION KINETICS OF APRAMYCIN IN GOATS

Article

Last updated: 23 Dec 2024

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Tags

Pharmacology

Abstract

The disposition kinetics and milk and urine concentration of apramycin were estimated in six goats. Following intramuscular and intravenous injection of 20 mg/kg b.wt., blood milk and urine samples were collected at 5, 15, 30 min., 1, 2, 4,6, 8,10,12 hours post injection. The collected samples were used for determination of apramycin concentration using the microbiological assay method. Following intramuscular injection of apramycin, the highest concentration in serum was recorded at 1 hour with t0.5(ab) value f 47.78 min. and t0.5 (β) £ 1.53 h. The peak milk and urine concentration was reached at 4 hours. Following intravenous injection of apramycin it follows two-compartment model with to t 95(a) 14.11 min. and tg 5 (β)) 3.22 h., Vc 0.97 L/kg. The Cl(B)) was 1.668 ml/kg. The mean systemic bioavailability was 78.25%. The protein binding percent of apramycin of serum and milk was 8.5% and 39.25% respectively.

DOI

10.21608/vmjg.1996.376575

Authors

First Name

EL-GENDI

Last Name

Y.

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University.

Email

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City

-

Orcid

-

First Name

HASHEM

Last Name

M.

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University.

Email

-

City

-

Orcid

-

First Name

AMER

Last Name

M.

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University.

Email

-

City

-

Orcid

-

Volume

44

Article Issue

2

Related Issue

50020

Issue Date

1996-04-01

Receive Date

2024-08-27

Publish Date

1996-04-01

Page Start

471

Page End

477

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 44_Issue 2_Pages 471-477.pdf

PDF . 4.2MB

Link

https://vmjg.journals.ekb.eg/article_376575.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=376575

Order

376,575

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

DISPOSITION KINETICS OF APRAMYCIN IN GOATS

Details

Type

Article

Created At

23 Dec 2024