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376570

EFFECT OF FLUNIXIN MEGLUMINE ON FERTIILITY OF MALE RATS

Article

Last updated: 23 Dec 2024

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-

Tags

Pharmacology

Abstract

The effect of flunixin meglumine (FM) in doses of 4 and 8 mg/kg. b. wt. on reproduction in rats were Studied. The tested doses were given daily intramuscularly to male rats for 65 days. Sex organs weights anal semen picture, testosterone, FSH and LH hormone levels as well as mating performance were the criteria used to evaluate the reproductive efficiency of treated rats. Prolonged i.m. administration of FM for 65 days to male rats, significantly decreased the weights of most genital organs, sperm cell concentration, sperm motility and live sperm percent associated with an increase in the percentages of dead and morphological abnormal spermatozoa of treated rats. A decrease in plasma testosterone level and increase in plasma LH and FSH levies was observed in the treated groups. Administration of the tested drug to male rats decreased their ability to mate females. Moreover,  the number of viable feti in some pregnant rats was Significantly decreased as compared with that of controls.

DOI

10.21608/vmjg.1996.376570

Authors

First Name

AFIFI

Last Name

.

MiddleName

-

Affiliation

Departments of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Email

-

City

-

Orcid

-

First Name

NEHAL

Last Name

A.

MiddleName

-

Affiliation

Departments of Pharmacology Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Email

-

City

-

Orcid

-

First Name

ATTIA

Last Name

A.

MiddleName

-

Affiliation

Departments of Physiology Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Email

-

City

-

Orcid

-

First Name

ATTIA

Last Name

Z.

MiddleName

-

Affiliation

Departments of Physiology Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Email

-

City

-

Orcid

-

Volume

44

Article Issue

2

Related Issue

50020

Issue Date

1996-04-01

Receive Date

2024-08-27

Publish Date

1996-04-01

Page Start

463

Page End

469

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 44_Issue 2_Pages 463-469.pdf

PDF . 4.5MB

Link

https://vmjg.journals.ekb.eg/article_376570.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=376570

Order

376,570

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

EFFECT OF FLUNIXIN MEGLUMINE ON FERTIILITY OF MALE RATS

Details

Type

Article

Created At

23 Dec 2024