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376557

PHARMACOKINETIC PROFILE OF PIPEMIDIC ACID INNORMAL AND NEPHRITIC RATS

Article

Last updated: 23 Dec 2024

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-

Tags

Pharmacology

Abstract

The pharmacokinetic profile, tissue distribution and residual content of pipemidic acid were studied in normal and nephritic rats. The maximum serum concentration was reached after 1 hr. in both normal and nephritic rats following oral administration of 50 mg/kg b. wt. Lower serum concentrations were detected in nephritic rats at corresponding time intervals as compared with healthy ones. Following. The intravenous injection of pipemidic acid, the resulting curves were best fitted to follow two compartment open model. The drug was highly. distributed in all tested tissues and completely disappeared from all tissues after 9 and 15 days in healthy and nephritic rats following its oral administration in a dose of 50 mg/kg b. wt. twice daily for 5 successive days.

DOI

10.21608/vmjg.1996.376557

Authors

First Name

A

Last Name

ABD EL-ATY

MiddleName

-

Affiliation

Department of Pharmacology, FACULTY OF Veterinary medicine ,Cairo University

Email

-

City

-

Orcid

-

First Name

A

Last Name

GOUDAH

MiddleName

-

Affiliation

Department of Pharmacology, FACULTY OF Veterinary medicine ,Cairo University

Email

-

City

-

Orcid

-

First Name

ATEF

Last Name

M.

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University

Email

-

City

-

Orcid

-

First Name

AMER

Last Name

M.

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University

Email

-

City

-

Orcid

-

First Name

El- BANNA

Last Name

A.

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University

Email

-

City

-

Orcid

-

First Name

SOLIMAN

Last Name

A.

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University

Email

-

City

-

Orcid

-

Volume

44

Article Issue

2

Related Issue

50020

Issue Date

1996-04-01

Receive Date

2024-08-27

Publish Date

1996-04-01

Page Start

453

Page End

461

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 44_Issue 2_Pages 453-461.pdf

PDF . 4.6MB

Link

https://vmjg.journals.ekb.eg/article_376557.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=376557

Order

376,557

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

PHARMACOKINETIC PROFILE OF PIPEMIDIC ACID INNORMAL AND NEPHRITIC RATS

Details

Type

Article

Created At

23 Dec 2024