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376554

EFFICACY AND PHARMACOKINETICS OF KANAMYCIN IN PSEUDOMONAS ELUORESCENS INFECTED CLARIAS LAZERA FISH

Article

Last updated: 03 Jan 2025

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Tags

Pharmacology

Abstract

 
Efficacy and pharmacokinetics of kanamycin were Studied in P. fluorescens infected Clarias lazera (Nile catfish). The clinical sings of P.fluorescens infection started after 12-24 hours post intraperitoneal inoculation. Kanamycin was injected in a single dose (20 mg/kg b.wt.) in the infected group and another apparently healthy control group. Recovery percent reached 73.33 in the infected fish group after 48 hours® post antibiotic injection Kanamycin was rapidly absorbed after intraperitoneal injection and reached its highest concentration 9.87+0.00059 and 9.20+0.85 µg/ml four hours post injection in normal and infected fish groups, respectively. Kanamycin was rapidly absorbed in infected fish ( a = 0.2726 + 0.002h"! and ty < & = 2.69 + 0.16 min.) than in normal fish a= 0.20420.009h"! and ty, a= 3.4420.14 min.). Kanamycin was rapidly excreted in infected fish with ty 5 B= 5.63+0.3764 hrs than in normal fish with tp 5 B= 7.55+1988 hrs. The interval between doses was short in infected fish 44.28 hrs than in normal fish 55.85hrs.

DOI

10.21608/vmjg.1996.376554

Authors

First Name

AMER

Last Name

M.

MiddleName

-

Affiliation

Department of Pharmacology, faculty of Vet. Medicine, Cairo Univ.

Email

-

City

-

Orcid

-

First Name

YONIS

Last Name

A.

MiddleName

-

Affiliation

Department of Fish Diseases, Animal Health Research Institute, Dokki.

Email

-

City

-

Orcid

-

First Name

ABD EL-AZIZ

Last Name

S.

MiddleName

-

Affiliation

Department of Fish Diseases, Animal Health Research Institute, Dokki.

Email

-

City

-

Orcid

-

First Name

NAGUIB

Last Name

M.

MiddleName

-

Affiliation

Department of Fish Diseases, Animal Health Research Institute, Dokki.

Email

-

City

-

Orcid

-

Volume

44

Article Issue

2

Related Issue

50020

Issue Date

1996-04-01

Receive Date

2024-08-27

Publish Date

1996-04-01

Page Start

443

Page End

451

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 44_Issue 2_Pages 443-451.pdf

PDF . 4.5MB

Link

https://vmjg.journals.ekb.eg/article_376554.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=376554

Order

376,554

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

EFFICACY AND PHARMACOKINETICS OF KANAMYCIN IN PSEUDOMONAS ELUORESCENS INFECTED CLARIAS LAZERA FISH

Details

Type

Article

Created At

23 Dec 2024