Aflatoxicosis syndrome was observed in 10 lactating female goats at Borg El-Arab, Egypt. Examination of feed samples showed that the available ration was contaminated with about 200 ppb. aflatoxin B₁ . A control apparently health group was taken from another farm in the same locality. Investigation of serum samples from affected female goats revealed increased activities of serum amino transferases, alkaline phosphatase, urea and creatinine concentrations, triacylglycerol and free fatty acids. Together with decreased serum total proteins, albumin, globulins, calcium, inorganic phosphorus, magnesium, potassium, vitamin A, vitamin E, total lipids, total cholesterol, high and low density lipoproteins and phospholipids concentrations. Aflatoxin residue (less than 1 to 2.5 ppb.) was detected in the milk of examined female goats.