Nile tilapia grow-out with an average initial weight of 24.3 gm were reared in 10 concrete ponds (8m² each) during a period of 18 weeks. The reared fish was stocked at a rate of 8 fish /m² and fed on 5 artificial diets with different levels of soybeans as partial and total fish meal replacer in these diets. At the end of cultured period, the weight gain was gradually increased with increasing the rearing period and the total weight gain in diet 2 (75% FM and 25% BFS) has a value of 107.3 gm/ fish which is nearly to the control diet (100% FM). The total fish production was 4.19 Kg/pond and 0.52 Kg/m² which is also approximately equal the values of control diet (4.43 kg/pond and 0.55 kg/m²). This indicates that, the full-fat soybeans is a promising feed ingredients for replacement the animal protein at 25% dietary protein in Nile tilapia diets. The results also cleared that the highest values of profit index (2.65,2.51) were obtained from fish fed diets 2.3 (25% and 50% BFS) With respect to the biochemical analysis, it was noticed that at diet 2 (75% FM and 25% BFS) the percent of protein in liver and muscle of fish take its suitable values (21, 96 g/100 gm liver tissue and 67.20% in dry matter of fish flesh). While the hepatic lipid and crude fat in muscle reached its lowest values (7.94 gm/100 gm liver tissue and 17.75% in dry matter) for fish fed same diet. The energy content also has its optimum values in fish fed diets 2,3 (25% and 50% BFS fish meal replacers).