The aim of the present work was to study the effects of consuming different types of Nile and marine fish on serum lipids profile, heamoglobin, protein metabolism(uric acid, urea albumin globulin total protein and creatinine) some electrolytes (sodium and potassium) and some levels of hepatic transaminase and alanine aminotransferase enzymes activity (AST&ALT) in normal male albino rats, weighing 150-155g. The results indicated that consuming diets contained different types of tested fish especially marine types caused significant hypolipidemic and hypocholesterolemic effects The cholesterol values significantly reduced by about :36.66% 34.13%,15.69% and 10.73% for staweridia, mackerel mabroka and kisher bayaid respectively while the lipids level reduced by about 22.90% 18.93%,18.81% and 4.82% for staweridia,mackerel mabroka and kisher bayaid respectively There were no significant difference in serum heamoglobin, tested electrolytes and tested protein metabolites measurements.