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375337

IMMUNOPOTENTIATION PROPERTIES OF PROPIOBACTERIUM GRANULOSUM VERSUS VITAMIN E IN CYLOPHOSHAMIDE IMMUNOSUPPRESSED CHICKENS.

Article

Last updated: 03 Jan 2025

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Tags

Avian diseases / production

Abstract

The immunosupressing effect of cyclophosphamide (CP) on cell mediated and humoral immunity has been proven with severe dramatic effect on serum transferrin (Tf) and immunoglobulins (IgG and IgM). Marked alterations in the morphologic features of major lymphoid organs and their weight/ body weight indices were evident. The Immunoassay revealed that Propiobacterium granulosum immunopotentiated the production of anti-sheep red blood cells (SRBCs) haemagglutinating (HA) antibodies 7 days post immunization till the end of the experiment (42 days) with a geometric mean ranging between 1.8-5.1. While vitamin E humbly sustained the HA titer at 14 and 21 days post immunization with a geometric mean of only 0.5 for each. Administration of Propiobacterium granulosum and vitamin E highly improved the level of serum Tf, IgG and IgM during the entire period of the experiment. They also significantly increased stimulation indices of lymphocyte transformation 7-14 days post immunization with SRBCs. Bursal / body weight index was significantly increased at 14 and 21 days post treatment with Propiobacterium granulosum and at 21 days post treatment with vitamin E over CP immunosuppressed non-treated control chickens. Histomorphologic features of bursa of Fabricus, thymus gland and spleen were markedly improved with Propiobacterium granulosum and vitamin E by post treatment day 7 and onwards. Protection percentage against E.coli challenge in the bioassay study reached 84.4 % or 68.9 % in CP immunosuppressed chicken groups immuno- potentiated with Propiobacterium granulosum or vitamin E respectively as compared with 48.9 % in immunosuppressed non-immunopotentiated group.

DOI

10.21608/vmjg.2003.375337

Authors

First Name

MANAL A

Last Name

AFIFY

MiddleName

-

Affiliation

Faculty of Veterinary Medicine, Cairo University.

Email

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City

-

Orcid

-

First Name

O

Last Name

ELSHAZLY

MiddleName

-

Affiliation

Faculty of Veterinary Medicine, Cairo University.

Email

-

City

-

Orcid

-

First Name

SAHAR A

Last Name

ZOUELFAKAR

MiddleName

-

Affiliation

Faculty of Veterinary Medicine, Cairo University.

Email

-

City

-

Orcid

-

First Name

IMAN B

Last Name

SHAHEED

MiddleName

-

Affiliation

Faculty of Veterinary Medicine, Cairo University.

Email

-

City

-

Orcid

-

First Name

M

Last Name

AWAAD

MiddleName

-

Affiliation

Faculty of Veterinary Medicine, Cairo University.

Email

-

City

-

Orcid

-

Volume

51

Article Issue

2

Related Issue

49904

Issue Date

2003-04-01

Receive Date

2024-08-21

Publish Date

2003-04-01

Page Start

257

Page End

272

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 51_Issue 2_Pages 257-272.pdf

PDF . 4.8MB

Link

https://vmjg.journals.ekb.eg/article_375337.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=375337

Order

375,337

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

IMMUNOPOTENTIATION PROPERTIES OF PROPIOBACTERIUM GRANULOSUM VERSUS VITAMIN E IN CYLOPHOSHAMIDE IMMUNOSUPPRESSED CHICKENS.

Details

Type

Article

Created At

23 Dec 2024