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375141

IMMUNOGENIC PROPERTIES OF OUTER MEMBRANE PROTEIN OF CAMPYLOBACTER JEJUNI IN CHICKS

Article

Last updated: 03 Jan 2025

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Subjects

-

Tags

Parasitology and parasitic diseases

Abstract

The immune response of chickens to outer membrane proteins (OMP) of Campylobacter jejuni (C. jejuni) was studied as a step in the search for Vaccine candidates. OMP of C. jejuni was administered I/M to native breed chicks at one Month of age for 4 times weekly intervals. Serum samples were collected for 4 successive weeks And immune response was measured by enzyme Linked immunosorbent assay (ELISA). Experimental chicks were challenged with 5 x 108 C. jejuni orally after one week of last vaccination. At The end of the experiment, the reisolation of C. jejuni was carried out and specimens for histopathOlogical examination were taken. The immunized Experimental birds showed increase in titres of Specific antibodies in sera than control group. The immunized and challenged experimental birds (group 1) had lower reisolation of C. jejuni (16.66%) than unimmunized challenged control Group (group 2) (85%), while there was no reisolation in control negative group (group 3). Histopathological examination revealed round cell aggregation and mild to moderate inflammatory changes in liver and intestine of group 1 while more severe degrees of inflammatory changes in Group 2. The results indicate that immunization can reduce the level of infection with C. jejuni But not completely protection.

DOI

10.21608/vmjg.2003.375141

Authors

First Name

EBTEHAL

Last Name

ABD-EL ATY

MiddleName

-

Affiliation

Serology Unit, Animal Health Research Institute, Dokki, Giza

Email

-

City

-

Orcid

-

First Name

NAGWA S

Last Name

RABIE

MiddleName

-

Affiliation

Dept. of Parasitology and Animal Diseases, National Research Center, Dokki, Giza

Email

-

City

-

Orcid

-

Volume

51

Article Issue

1

Related Issue

49903

Issue Date

2003-01-01

Receive Date

2024-08-21

Publish Date

2003-01-01

Page Start

95

Page End

104

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 51_Issue 1_Pages 95-104.pdf

PDF . 2.8MB

Link

https://vmjg.journals.ekb.eg/article_375141.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=375141

Order

375,141

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

IMMUNOGENIC PROPERTIES OF OUTER MEMBRANE PROTEIN OF CAMPYLOBACTER JEJUNI IN CHICKS

Details

Type

Article

Created At

23 Dec 2024