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377231

EFFECT OF AFLATOXICOSIS ON THE KINETIC BEHAVIOUR OF CEFTIOFUR IN CHICKENS

Article

Last updated: 23 Dec 2024

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Subjects

-

Tags

Biochemistry
Pharmacology

Abstract

The kinetic behaviour of ceftiofur sodium was studied in aflatoxin treated (for 30 days) and non-treated chickens following oral, intramuscular and intravenous administrations of 10 mg kg-1B. Wt. Aflatoxicosis resulted in a significant decrease In ceftiofur serum concentration in the treated rather than non-treated chickens following oral and intravenous administration. The kinetic behaviour showed that following intravenous injection, the elimination half life time t 0.5 (el) was significantly shorter in the treated (1.75 +0.03 h) than in non-treated chickens (4.23 + 0.05 h) following oral administration, the kinetic behaviour revealed long absorption half-life (t 0.5 (ab) ,62.74 ±1.59 min) in the treated than non-treated chicken (50.46± 5.07 min) ,with low Cmax 23.25 ±0.42 ug ml-1 at long tmax (3.05 ± 0.07 h) In treated than non treated chickens( Cmax 27.83 ± 1.28 at tmax 2.39 ± 0.07 h)

DOI

10.21608/vmjg.1998.377231

Authors

First Name

AZIZA M. M

Last Name

AMER

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Vet. Medicine, Cairo Unviersity

Email

-

City

-

Orcid

-

First Name

EISHA M. M.

Last Name

FAHIM

MiddleName

-

Affiliation

Biochemistry Department, Animal Health Research Institute, Dokki.

Email

-

City

-

Orcid

-

First Name

RAWIA K.

Last Name

IBRAHIM

MiddleName

-

Affiliation

Biochemistry Department, Animal Health Research Institute, Dokki.

Email

-

City

-

Orcid

-

Volume

46

Article Issue

1

Related Issue

49899

Issue Date

1998-01-01

Receive Date

2024-08-29

Publish Date

1998-01-01

Page Start

17

Page End

27

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 46_Issue 1_Pages 17-27.pdf

PDF . 3.4MB

Link

https://vmjg.journals.ekb.eg/article_377231.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=377231

Order

377,231

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

EFFECT OF AFLATOXICOSIS ON THE KINETIC BEHAVIOUR OF CEFTIOFUR IN CHICKENS

Details

Type

Article

Created At

23 Dec 2024