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372269

EFFECT OF PROSTAGLANDIN E2 (PGE2) ON CARBOHYDRATE METABOLISM IN NORMOTENSIVE AND INDUCED HYPERTENSIVE RATS

Article

Last updated: 03 Jan 2025

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Subjects

-

Tags

Theriogenology / reproductive technology

Abstract

The present study was conducted to investigate the effect of the vasodilator PGE2 on carbohydrate metabolism in both of normotensive and hypertensive adult male rats. PGE2 was injected intraperitoneally in a dose of 40μg/kg body weight per day to normotensive and hypertensive groups for 8, 16, and 24 days. Hypertension was induced in normal rats by administration one subcutaneous injection of an aqueous suspension of 25-mg/kg-body weight of deoxycorticosterone acetate (DOCA) per week. Moreover, a saline solution was given to rats to drink during the 4-weeks of hypertension induction periods. PGE2 caused significant glycogenolytic effect with a corresponding hyperglycemia after 16 and 24 days of treatment in normotensives and hypertensives. However, Glucose-6-phosphatase exhibited insignificant increase throughout the experimental periods. Lactate levels in serum increased insignificantly, but the increase reached significant value after 24 days of treatment in normotensive animals. Activity of lactate dehydrogenase in serum and liver did not change significantly after injecting PGE2 at any time interval. Long term administration of low doses of PGE2 caused significant increases in serum glucose with corresponding declines in liver glycogen levels in both normotensive and hypertensive rats.

DOI

10.21608/vmjg.2001.372269

Authors

First Name

FATMA A

Last Name

EL NEGMY

MiddleName

-

Affiliation

Zoology Department, Girls College for Arts, Science and Education, Ain Shams University

Email

-

City

-

Orcid

-

First Name

M

Last Name

YASSIN

MiddleName

-

Affiliation

Department of Biology, Faculty of Science, Islamic University-Gaza-Palestine

Email

-

City

-

Orcid

-

First Name

A

Last Name

ASHOUR

MiddleName

-

Affiliation

College of Education-Gaza-Palestine

Email

-

City

-

Orcid

-

First Name

S

Last Name

HASUNEH

MiddleName

-

Affiliation

College of Education-Gaza-Palestine

Email

-

City

-

Orcid

-

Volume

49

Article Issue

4

Related Issue

49663

Issue Date

2001-10-01

Receive Date

2024-08-06

Publish Date

2001-10-01

Page Start

523

Page End

530

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 49_Issue 4_Pages 523-530.pdf

PDF . 2.8MB

Link

https://vmjg.journals.ekb.eg/article_372269.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=372269

Order

372,269

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

EFFECT OF PROSTAGLANDIN E2 (PGE2) ON CARBOHYDRATE METABOLISM IN NORMOTENSIVE AND INDUCED HYPERTENSIVE RATS

Details

Type

Article

Created At

23 Dec 2024