During the period from February 1998 to January 2000; clinical and laboratory examination were carried out on 521 donkeys at different localities in Zagazig, Sharkia Governorate. Twenty-eight animals out of them were proved to be infected with ringworm. The lesions are characterized by circumscribed hairless areas of about 1-3 cm in diameter; lesions may be localized or generalized and distributed over the neck, shoulders, limbs and flanks with itching in some cases high incidence of clinical cases were found in winter especially in young animals and in adult animals under stress. Microsporum canis (M.canis), Trichophyton equi- num (T. equinum) and Trichophyton verrucosum (T. verrucosum) were isolated and identified on the basis of characteristic microscopical examina- tion of the hair and skin scraping and morphologi- cal appearance of the colonies on selected media. Tequinum The isolated M.canis, and T.verrucosum were sensitive to griseofulvin and resistant to nystatin.High efficiency of the local treatment and clinical improvement were observed when treatment with either Mycoderm, or Tr. Iodin 2.5 % or garlic ex- tract. Also systemic treatment with griseofulvin was highly effective in generalized infection in addition to supplementation of the diet particular- ly with vitamin A. Dermatophytes could not be isolated from sam- ples collected from treated animals at two weeks intervals and up to the eighth week post treat- ment. Control measures were applied through disinfection of the stables with a spray containing 2.0% formaldehyde and 1.0% caustic soda.