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371862

GENOTOXIC EFFECT OF HOSTATHION IN MICE

Article

Last updated: 03 Jan 2025

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Subjects

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Tags

Breeding / genetics

Abstract

The genotoxic potential of technical hostathion was studied in the in vivo mouse system. The test Parameters used were chromosomal aberrations Assay and mitotic index in bone marrow cells; and Meiotic chromosomal aberrations assay and Meiotic index in germinal cells. Three dose levels (2.8, 4.2 and 5.6 mg/kg. b.wt.) were used for 3 And 5 days subacute treatments after oral administrations. Chromosome aberrations were observed In bone marrow cells and in diakineses-metaphase I cells from the testes. The dose and time yield effects statistically analysed. The results demonstrated that hostathion induced a significant structural chromosomal damages in somatic and Germinal cells as well as peridiploidy of numerical aberrations in somatic cells which were dose- And time dependent at all dose levels. A dose dependent significant decrease was observed in Mitotic and meiotic indices of mice cells. It was Concluded that hostathion has genotoxic effects. Therefore, the use of this pesticide in our life Must be restricted.

DOI

10.21608/vmjg.2001.371862

Authors

First Name

I

Last Name

FARAG

MiddleName

-

Affiliation

Cell Biology Department, National Research Centre, Dokki, Cairo, Egypt

Email

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City

-

Orcid

-

First Name

K

Last Name

ABDEL AZIZ

MiddleName

-

Affiliation

Cell Biology Department, National Research Centre, Dokki, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

M

Last Name

ZAHER

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Cairo Univ., Egypt.

Email

-

City

-

Orcid

-

First Name

H

Last Name

DARWISH

MiddleName

-

Affiliation

Cell Biology Department, National Research Centre, Dokki, Cairo, Egypt

Email

-

City

-

Orcid

-

Volume

49

Article Issue

1

Related Issue

49660

Issue Date

2001-01-01

Receive Date

2024-08-04

Publish Date

2001-01-01

Page Start

59

Page End

69

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 49_Issue 1_Pages 59-69.pdf

PDF . 3.2MB

Link

https://vmjg.journals.ekb.eg/article_371862.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=371862

Order

371,862

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

GENOTOXIC EFFECT OF HOSTATHION IN MICE

Details

Type

Article

Created At

23 Dec 2024