Egg and tissue culture adapted infectious bron-chitis vaccines were used in ovo-vaccination at 18 days embryonation, one-day-old chicks and 66 weeks old hens. It was found that the hatcha-bility was decreased to 54% and 60% on using  and tissue culture vaccine, respectively.Both vaccines resulted in a good protection per-centage 90%, 85% and 85% for egg and tissue culture vaccine, respectively in case of ovo vac-“ination, 80% and 75% in case of one day old “vaccination and 85% for both vaccines in case of hens Vaccination with closely similar immune response aS Measure om Fluorescent Antibody Technique ELisa nd Linked Immunosorbent Assay tests demageglutination Inhibition (HI) tests.