The present study was conducted on male Newze-land rabbits to investigate the effects of bovine somatotropin and salbutamol on fat deposition. The recorded findings revealed that both promo-‘ors decreased longissimus muscle fat concentra-lion and increased protein: fat ratio and the effects of salbutamol are more pronounced. Growth pro-Motors decreased fat deposition at multiple levels, gross level by decreasing the weight of selected 'at depots and salbutamol is more effective than “Somatotropin, Growth promotors increased plas-"2 total lipids, triacylglycerols, total cholesterol high-density lipoproteins (HDL) and ve low.density lipoproteins 4 tow.iy inom, (VLDL) and reduced low- Proteins (LDL) and salbutamol was some potent than somatotropin. Plasma leptin as an index for whole body fat mass , was decreased is somatotropin injected and salbutamol fed rabbits , moreover bovine somatotropin and salbutamol increased plasma Apo-1!/Fas concentration, as an index for programmed cell death or apoptosis. In conclusion, the investigated promotors reduced the fat deposition at multiple levels; gross, bio-chemical and hormonal levels and these effects were not only confined to internal fat depots but also extended to intramuscular fat.