Fifty cow heiffers (Balady), 1-2 years age, al Sarnga, Dakahlia Goverorate were examined for infestation with ccto and endoparasites and classificd into three groups. Group | infested with ectoparasites, group II infested with  endoparasites and group III those free from any infestation. Parasitized animals were treated with a single subcutancous dose of moxidectin or doramectin at dose level of 200 ug/kg. B. Wt. Parasitological examinations using a hand lens and microscopically were performed every five days for five wecks post-treatment with moxidectin or doramectin. The study revealed that both drugs were highly effective (more than90 %) on the 5 day post-treatment against Oesphagostomum radiatum, Haemonchus sp and | ‘whereas, the effectiveness against Nematodirus sp. And Trichuris sp. were Iess than 90 % Moxidectin .was more effective than doramcctin in reduction, of egg counts of most tested endoparasites, Administration of moxidectin or doramectin resulted in an climination of most sucking, lice and mites from animal body on 5h day post-treatment. Haematological and biochemical parameters in infested animals were improved after treatment with both drugs.