Vibrosis ts an cconomically damaging infectious discasc of cultured fresh water fish characterizedby red necrotic Icsions of the abdominal muscula-ture. cxophthalmici, and erythema at the bases ofthe fins and around the vent. Vibro anguillarum was recovered from 62% of cxamincd clinically; affected Tilapia nilotica fish. The percentages of ‘isolation from skin Iesions, muscle, kidney, spleen and liver tissues were 35%, 22%, 60%,48% and 43% respectively. The highest recovery rate of Vibro anguillarum was observed in kidney (60%)The main characteristic histopathological changes as well as the public health importance of the dis-vase were discussed.