The effect of alcoholic extract of Artemisia alba in doses of 25.2 and 126 mg/kg. b.wt on male rat fertility were studied. The tested doses were given orally to male rats for 65 successive days. Sex or- cans weights, seminal characters and histopathological examination of the male genital organs were used to evaluate the reproductive efficiency of the treated rats. A significant decrease in the weights of genital organs, sperm cell concentration and percentages of sperm motility and seminiferous tubules containing spermatozoa with an increase in the percentage of spermatozoal abnormalities of treated rats. histopathological examination of genital organs revealed that alcoholic extract of Artemisia alba caused testicular lesions characterized by moderate to severe degenerative changes of spermatogonial cells and partial arrest of spermatogenesis.