The present study was carried out to investigate picture of exposure to fluoride in hens nearby phosphate fertilizer producing factory at Assiut governorate, Egypt. Twenty hens selected from farmer's houses showing some skeletal deformity were investigated in this study. The gross appearance of bone revealed ossification and deformity. Bone analysis Showed an increase in dry matter %, Ash % and Ca content. Thyroxine, Triodothyronin and iodine is showed an apparent increase in serum. Red blood cells, packed cell volume and hemoglobin percent showed also an elevation than control hens. Total leukocyte count was decreased in investigated hens. Albumin/globulin ratio showed decreased values as well as total proteins and calcium in serum. Tissue samples of liver, Kidney, lung, heart and thymus were showing a necrobiotic and degenerative changes.