The present work was conducted to study the interaction between aflatoxin, Candida albicans and Aspergillus Fumigatus, 300 one day old chicks were used in two experiments, 150 were used in two experiment and the birds in each experiment were divided into 5 groups, 30 chicks in each. The 1st group in both the 1st and 2nd experiments were given direct free from aflatoxin, while the other groups were given diet contained aflatoxins for 6 weeks. After two weeks, all the birds in the 1st experiment were inoculated with one mi. of 3x103 Candida albicans while those related to the 2nd experiment were inoculated with one ml. of 4 x 109 species of Aspergillus fumigatus. The histopathological results indicated that aflatoxin increased the infectivity (as measured by lesion score) in C. albicans (66.6% 73.3%, 86% and 93.3%) and also in A. fumigatus (533%, 66.6%, 73.3% and 93,3%) respectively.