Boscat white rabbits were vaccinated with Hyalomma dromedarii  tick eggs antigen (Antigen I) and sex organs with midgut antigen (Antigen II). Both antigen were exposed to electrophorytic analysis . The rabbits received two inoculations subcutaneously on 0 day and alter 2 weeks. The effect of the immunity Induced was determined by enzyme linked immunosorbent assay (ELISA) and by infesting the rabbits with adult H.dromdarii ticks. In immunized rabbits, the antibody titer was detected in serum. A significant reduction in tick weight, egg mass weight, oviposition period and percentage of egg hatchability were found. Three specific immunogenic bands were detected for antigen I and four for antigen II. Sex organs with midgut antigen induced best protection of eggs antigen.