The effect of feeding avoparcin and virginiamycin (10 ppm) alone or in combination with diclazuril (1 ppm) to growing rabbits for 10 successive weeks on absolute body weight, body gain and feed efficiency were studied. Moreover, their effects on blood picture and the activity of AST, ALT as well as urea and creatinine levels were also investigated. In addition, the residual patterns of avoparcin and virginiamycin were also demonstrated using the microbiological assay technique. Avoparcin or Virginiamycin supplementation with the basal ration significantly increased the absolute body weight (5.7 or 8.8%), amount of feed consumed (3.2 or 1.6 %) as well as plucked weight, Avoparcin was found to be compatible with diclazuril as their combination induced large improvement in the body weights (10.6 %) and the amount of feed consumed (6.2 %). Combination of diclazuril with virginiamycin didnot alter the absolute body weight and the weight gain, but increased the amount of feed consumed(4.5 %) as compared with group fed virginiamycin alone. Avoparcin or virginiamycin alone and combination of  diclazuril with avoparcin significantly increased R.B. Cs count, hemoglobin content and PCV. Combination of diclazuril with avoparcin increased the activity of AST and ALT and that with virginiamycin increased AST and ALT activity as well as urea and creatinine levels. No residues of cither avoparcin or virginiamycin were detected at the end of the experiment in organs and tissues of rabbits fed 10 ppm for 10 successive weeks. In conclusion, feeding  avoparcin or Virginiamycin to growing rabbits at 10 ppm stimulates growth, feed efficiency and blood picture, Diclazuril (1ppm) was found to be more compatible with avoparcin than virginiamycin.