A total of  twelve seronegative sheep against infectious Bovine Rhinotracheities (IBR), Bovine Vial Diarthoea (BVD), Parainfluinza-3^a (PI-3) and Rift Valley Fever (RVF) was randomly divided into four groups. One group received (pneumo-3) vaccine alone, another one simultaneously received pneumo-3 and Rift Valley (RVF) vaccine. The third group received RVF alone and the fourth group served as a non-vaccinated control. No side effects or clinical reaction or disease syndrome could be detected in any of the vaccinated groups. All tested animals remained Clinically normal throughout an observed period of 6 weeks post vaccination. Very Satisfactory serological responses were detected in animals simultaneously inoculated with  both vaccines as well as in animals soldy vaccinated with either vaccine. No significant differences could be found in IBR, BVD and PI-3 serum neutralizing antibody titres of all groups of vaccinated animals also there is no significant difference could be found in RVF serum neutralizing antibody titre. The results clearly indicated the safety and efficacy of simultaneous inoculation of sheep with pneumo-3 with RVF vaccines without impairing the response to individual vaccines and no antagonism between the vaccination penumo-3 and RVF also this good medication for preparing combined vaccine of pneumo-3 and RVF.