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369353

COMPARATIVE PATHOLOGICAL AND IMMUNOLOGICAL STUDIES ON DIFFERENT OIL ADJUVANATED INACTIVATED NEWCASTLE DISEASE VIRUS VACCINES (NDVV) PRIVATE

Article

Last updated: 03 Jan 2025

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Subjects

-

Tags

Immunology / vaccine / diagnosis

Abstract

The present study was applied to evaluate the physical properties of ISA-70 Marcol-52 and paraffin oil adjuvant used in commercial vaccines and describes the pathological changes and serological response of chickens after intramuscular injection. A total of 140 three-week old white Leghorn chickens, specific pathogen free were obtained from Koum Osheim, Fayoum Governorate. Chickens were divided into four equal groups one of them is control, the other three groups were in- jected intramuscularly with the following oil adjuvant emulsions containing inactivated Newcastle disease virus (NDV) antigen: ISA-70, Marcol-52 And paraffin. Five chickens of each group were Sacrificed at 72 hours and at 1, 2, 4, 8, 12 and 16 weeks post-vaccination. The pathological reaction induced by ISA-70 emulsion was characterized by focal aggregation of macrophages, lymphocytes, epithelioid cells and fibroblasts around the small cysts in muscle. These lesions peaked at 2 weeks post-injection and considered as mild pathological changes if compared with Marcol-52 and paraffin oil adjuVant. The serological findings revealed that the enhancing effect of ISA-70 on NDV antigen was more than that of Marcol-52 and paraffin oil adjuVant.

DOI

10.21608/vmjg.2002.369353

Authors

First Name

AMAL

Last Name

ABD EL-HADY

MiddleName

-

Affiliation

Central Laboratory for Control of Veterinary Biologics, Abbasia, Cairo.

Email

-

City

-

Orcid

-

First Name

ELHAM

Last Name

EL-EBIARY

MiddleName

-

Affiliation

Central Laboratory for Control of Veterinary Biologics, Abbasia, Cairo.

Email

-

City

-

Orcid

-

First Name

a

Last Name

OSMAN

MiddleName

-

Affiliation

Department of Pathology, Faculty of Veterinary Medicine, Cairo University

Email

-

City

-

Orcid

-

First Name

NADIA

Last Name

HASSAN

MiddleName

-

Affiliation

Veterinary Serum and Vaccine Research Institute, Abbasia, Cairo.

Email

-

City

-

Orcid

-

Volume

50

Article Issue

4

Related Issue

49349

Issue Date

2002-10-01

Receive Date

2024-07-26

Publish Date

2002-10-01

Page Start

769

Page End

778

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 50_Issue 4_Pages 769-778.pdf

PDF . 3.0MB

Link

https://vmjg.journals.ekb.eg/article_369353.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=369353

Order

369,353

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

COMPARATIVE PATHOLOGICAL AND IMMUNOLOGICAL STUDIES ON DIFFERENT OIL ADJUVANATED INACTIVATED NEWCASTLE DISEASE VIRUS VACCINES (NDVV) PRIVATE

Details

Type

Article

Created At

23 Dec 2024